He will be in Kenya from November 25 to 27, spend the next two days in Uganda and travel on to the Central African Republic (CAR), where the trip will end on November 30, according to a Vatican itinerary published Saturday.
The three countries have significant Catholic communities and have been troubled by civil conflicts and violence, which will increase concerns surrounding possible attacks during the visit, AFP reported.
In Nairobi, Francis will tour the Kangemi slum, home to some 100,000 people who live in shacks without sewerage systems, including 20,000 who belong to the local Catholic parish.
The pontiff will meet with representatives of Kenya's multi-faith community in a bid to promote inter-religious dialogue.
And in Bangui, the CAR capital, the pontiff will tour a refugee camp before visiting the city's central Koudoukou mosque to meet representatives of the Muslim community.